South America is one of the most varied and rewarding continents to explore. From world‑class natural wonders to rich cultural heritage and unforgettable food and wine experiences, it offers something for every kind of traveller — whether you’re visiting for the first time or returning to see more.

At Wanderlust Travel Experts, we design South America journeys that reflect how you like to travel. With enough time (three weeks is ideal), many of the experiences below can be combined into a seamless, personalised adventure.

Use this guide as inspiration as you dream about your South American holiday.

Content adapted and credited to Laura Pattara, originally written for Viva Expeditions (6 March 2025).

Machu Picchu is not the only remnant of the Inca civilization in the Andes, but it is the most iconic.

1. Follow in the Footsteps of the Mighty Incas

The legacy of the Inca Empire continues to shape modern‑day Peru. Cusco, once the heart of the empire, is the gateway to the Sacred Valley, where terraced fields, ancient ruins and traditional villages provide deep cultural insight.

At its pinnacle lies Machu Picchu — one of South America’s most iconic sights. Whether you arrive by train or on foot, this extraordinary place delivers a powerful sense of history and wonder that stays with you long after you leave.

2. Marvel at the Power of Iguazu Falls

Spanning 2.7 kilometres across the Argentine–Brazilian border, Iguazu Falls is one of the Seven Natural Wonders of the World. The sheer scale and thunderous energy of the cascades are breathtaking.

Exploring both sides of the falls reveals different perspectives, from panoramic viewpoints to immersive rainforest walkways that bring you remarkably close to the action.

Take a helicopter ride over Iguazu Falls for the ultimate bird's eye view—this is one of the best things to do in South America if you love thrilling experiences.

3. Savor Fine Wines in the Heart of Chile

Santiago is an understated yet rewarding capital, offering excellent dining, architecture and museums. Its true surprise lies just beyond the city, in Chile’s celebrated wine valleys.

From relaxed tastings to immersive winery stays, enjoying Chilean wine against a backdrop of rolling vineyards and the Andes is a highlight for food‑ and wine‑loving travellers.

4. Fall in Love with Santiago and Ride Historic Elevators in Valparaíso

Santiago is a city best enjoyed at an easy pace — exploring neighbourhoods, sampling local food and soaking up views from San Cristóbal Hill.

A short journey west lies Valparaíso, Chile’s cultural capital. Its colourful hillsides, street art and historic ascensores (funicular elevators) are part of its UNESCO World Heritage status and give the city its unmistakable character.

More than a mere springboard for South American adventures, Santiago is a thoroughly enjoyable capital to explore.

5. Enjoy a Fascinating Insider‑Guided Tour in La Paz

La Paz offers one of South America’s most unique city experiences. Guided tours reveal striking contrasts — from vibrant indigenous markets to colonial squares and modern neighbourhoods.

Cable cars provide sweeping views across the city, while nearby highlights such as the Valley of the Moon add a surreal edge. Experiences led by local guides offer meaningful insight into daily life and culture.

6. Dive Into Lima’s Historic Catacombs

Lima rewards travellers who take the time to explore beyond its role as a gateway city. Alongside its acclaimed food scene and colonial architecture lies one of its most intriguing attractions — the catacombs beneath the Convent of St Francis.

Discovered in the 1940s, these underground chambers offer a fascinating glimpse into the city’s layered past.

7. Lose Yourself in the Charm of Buenos Aires

Buenos Aires blends European elegance with unmistakable Latin spirit. Highlights include the ornate Recoleta Cemetery, vibrant neighbourhoods and a rich cultural scene.

No visit is complete without experiencing tango — whether in an intimate venue or a polished stage performance paired with traditional Argentine cuisine.

8. Indulge in a Feast for All Your Senses in Quito

Quito is a city to experience rather than simply visit. Its beautifully preserved historic centre, dramatic Andean setting and strong cultural identity make it quietly captivating.

Walking tours bring the city to life through food, craft and storytelling, while streets like La Ronda showcase the passion of local artisans.

The Uros people of Lake Titicaca, living as they have been for centuries.

9. Cruise the Sacred Waters of Lake Titicaca

Straddling the border of Peru and Bolivia, Lake Titicaca is the world’s highest navigable lake. Its deep blue waters and mountain backdrop create a truly memorable setting.

Visits to the floating Uros Islands introduce you to communities maintaining centuries‑old traditions, offering a rare perspective on a way of life that continues today.

10. Get Into the Carnival Spirit in Rio de Janeiro

Rio de Janeiro is South America’s most visited city and home to the world‑famous Carnival. Each year, music, dance and elaborate parades transform the streets.

For those visiting during Carnival, a night at the Sambadrome delivers an unforgettable celebration of Brazil’s rhythm, colour and zest for life.

11. Discover the Maras Salt Ponds in Peru

Hidden in the Sacred Valley, the Maras salt terraces pre‑date the Inca civilisation. Fed by a natural salt spring, the geometric pools are still harvested by local families today.

A guided visit reveals the ingenuity behind this ancient system and offers a quieter, lesser‑known highlight of Peru.

The Maras Salt Ponds are one of Peru’s lesser-known historic treasures. The geometric terraces shimmer in the sunlight, creating an utterly surreal landscape.

12. Explore the Amazon Rainforest

The Amazon is one of the most biodiverse regions on earth and a deeply immersive travel experience. You can explore by river cruise or stay in an eco‑lodge, depending on the season.

Daily excursions reveal remarkable wildlife and provide insight into the traditions of the communities who call the rainforest home.

13. Get Swept Away by Patagonia’s Beauty

Patagonia is a land of dramatic scale and raw wilderness. From Argentina’s Perito Moreno Glacier to Chile’s Torres del Paine National Park, the scenery is unforgettable.

Perfect for nature lovers and active travellers, Patagonia rewards those who venture into its wide‑open landscapes.

14. Walk Among Ancient Giants in the Galapagos

The Galapagos Islands are unlike anywhere else on earth. Their isolation has created extraordinary wildlife found nowhere else.

Meeting the giant tortoises — ancient creatures that have roamed the islands for millions of years — is a powerful and humbling experience. Most visitors explore the islands by small‑ship cruise.

A Galapagos cruise is a bucket-list experience for wildlife lovers.

15. Delight in Local Flavours Across the Continent

From empanadas in Argentina to Brazilian feijoada and coastal seafood stews, South America’s cuisine reflects its diversity.

Sampling everything from street food to fine dining offers an authentic connection to the cultures you encounter along the way.

Ready to Explore South America?

Whether you’re drawn to iconic landmarks, hidden cultural gems or unforgettable food and wine experiences, South America offers endless possibilities.

Talk to your Wanderlust Travel Experts advisor about creating a personalised South American journey that brings your bucket‑list experiences to life.

Best Things to Do in South America